Our own clinical lab, in Philadelphia.
Biomeme has spent almost 15 years building tests that read DNA and RNA, and the instruments that run them, first for field biologists, the military, and diagnostic labs. During COVID, the team learned to run high-complexity labs and testing at many sites.
Biomeme Labs is the next step: our own clinical lab, where we offer tests directly to people. The Inflammation Compass is its first.
Certification
CLIA certified
ID # 39D2229561
High-complexity lab
Sequencing depth
~30M read pairs
Illumina NovaSeq
Stranded 2×150 bp pairs
Specimen
PAXgene
Whole blood
RNA stabilized when the sample is taken
Report
Six readings
38 pathways
Plus the immune cell mix
Four commitments, made at the start.
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We never sell your data.
Your results are used for the test you ordered. Whether they join the reference group or are used in research is your choice.
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Your raw data is yours.
The data your sample produces belongs to you.
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We show how every result is calculated.
Each result shows what was measured, how it was calculated, and with whom it was compared.
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We sell no supplements.
We have nothing else to sell you, so we have no reason to steer you.
From one tube of blood to six readings.
RNA, the working copies of genes, is measured in your blood sample and summarized into 38 pathways: groups of genes that work together. A statistical model with fixed weights combines them into six readings, and the immune cell mix is estimated from the same data.
The test is designed for baseline and follow-up comparison. Later reports show which readings moved since earlier samples, and by how much.
High-depth RNA sequencing
PAXgene whole-blood RNA stabilization preserves the expression profile at draw, minimizing ex vivo changes. Stranded library prep with globin and rRNA depletion, ERCC synthetic spike-ins, and ~30M paired-end reads (2×150 bp) on Illumina NovaSeq.
Within-sample scoring
Each pathway is scored relative to the overall gene activity in the same sample. The sample acts as its own frame of reference, making scores robust to library-depth and run-to-run technical differences.
Reference-based deconvolution
Digital cytometry built on established, published immune-cell reference frameworks. Helps address the bulk-blood confound by separating estimated leukocyte composition from cell activation states.
CLIA quality assurance
Each sample must pass quality checks in the lab, and a sample that fails is re-processed or re-collected, never reported. The laboratory operates under specimen tracking and ongoing proficiency testing.
Built on peer-reviewed biology
The pathways are drawn from peer-reviewed research and pathway databases and checked against a reference collection of human blood transcriptomes. Three readings follow the signals that start a response and three follow the signals that end it.
Proven at scale during COVID-19
During the COVID-19 pandemic, Biomeme Labs brought a molecular test to market and partnered with major organizations — including film and television productions — to run testing at many sites.
Production & studio partners tested at scale
Why we built the Inflammation Compass.
Three things have arrived at once: almost 15 years of building tools that let anyone read DNA and RNA, a decade of research on how inflammation shapes health, and sequencing fast and affordable enough to offer to everyone.
Two of us were training for our first marathon when we tried it on ourselves: a blood sample every week, and our own inflammation response changing in front of us. After that, the question was why we weren’t already offering it to everyone. Now we are, and your first sample starts your personal baseline.
Start with your baseline.
Your first sample starts your personal baseline.
$389 per test, or $365 each when you order 4 or more. Mobile phlebotomy and shipping included.