See What's Happening Inside Your Cells
Longevity isn't guesswork. The Inflammation Compass™ measures whole-blood gene expression across 3 Health Domains — Activation, Antiviral Response, and Resolution — plus cellular deconvolution, giving individuals pursuing longevity protocols an objective molecular window into systemic inflammaging and active cellular resolution.
Aging Happens at the
Cellular Level
Most longevity interventions — NMN, NR, rapamycin, metformin, peptides — target cellular homeostasis. But standard health metrics provide zero visibility into whether systemic inflammatory tone is calming or if active resolution capacity is engaged.
The Supplement Gap
You're taking NMN, NR, or longevity compounds, but is your systemic physiology responding? Are inflammatory programs quieting down? Without transcriptomic data, you're guessing.
The Aging Clock Blind Spot
Epigenetic clocks estimate biological age as a static summary score, but they cannot tell you whether active inflammatory cascades or suppressed resolution programs are driving cellular stress right now.
Standard Labs Miss the Signal
Cholesterol, fasting glucose, and hs-CRP are lagging indicators. They signal damage after it occurs, missing real-time shifts in circulating leukocyte gene transcription and resolution capacity.
One Intervention, Systemic Arc
Longevity protocols influence interconnected cellular programs. Whole-blood transcriptomic profiling captures the real-time shift in systemic inflammation, active resolution, and immune resilience.
The 3 Health Domains
Behind Systemic Inflammaging
Rather than unvalidated standalone assays for isolated tissue enzymes, the Inflammation Compass™ measures whole-blood gene expression across the universal 3 Health Domains plus cellular deconvolution — providing an objective, CLIA-certified window into systemic inflammaging and active resolution capacity for individuals pursuing longevity protocols.
Activation
Innate & Effector Programs
Quantifies danger sensing, IL-1 signaling, neutrophil/monocyte deployment, and oxidative stress programs. Persistent elevation drives chronic inflammaging; effective longevity protocols help calm this baseline.
Antiviral Response
Type I Interferon Cascade
Measures baseline interferon-stimulated gene modules in circulating leukocytes. Distinguishes sterile metabolic/aging inflammation from intercurrent viral exposure, vaccinations, or transient interferon pathway activation.
Resolution
Stand-Down & Clearance
Quantifies active biological stand-down checkpoints and apoptotic clearance machinery. High resolution capacity is a hallmark of youthful cellular resilience and healthy biological recovery.
Cellular Deconvolution
Census Plus Orders
Deconvolves whole-blood RNA into circulating immune cell subsets (neutrophils, monocytes, naive and memory lymphocytes) — distinguishing true gene regulation from shifts in cell population counts.
How Longevity Biology Interfaces with Systemic Inflammation
Longevity interventions target fundamental hallmarks of aging. While the Inflammation Compass™ does not perform isolated biopsy assays or dedicated tissue enzyme panels, circulating leukocyte gene expression provides an objective window into how these longevity mechanisms register systemically:
NAD+ & Sirtuins
SIRT1-7 · NAMPT · CD38
Intracellular NAD+ fuels sirtuins that deacetylate NF-κB, suppressing chronic innate activation and promoting leukocyte metabolic resilience.
Mitochondrial Homeostasis
PGC-1α · TFAM · Complex I-V
Intact mitochondrial biogenesis prevents mtROS leakage and mitochondrial DNA release that trigger innate cGAS-STING inflammatory cascades.
Cellular Senescence
p16INK4a · p21 · SASP
Senescent cells secrete pro-inflammatory SASP factors into systemic circulation, elevating whole-blood Activation domain pathway scores.
Autophagy & Cleanup
ATG · LC3 · mTOR
Autophagic recycling of damaged organelles supports leukocyte homeostatic stand-down and active apoptotic clearance machinery in Resolution.
Inflammatory Aging
NF-κB · IL-1 · TNF-α · IL-6
Chronic low-grade myeloid activation without resolution is the core phenotype of inflammaging directly tracked by the Inflammation Compass™.
Telomere Biology
hTERT · TERC · Shelterin
Critical telomeric shortening induces persistent DNA damage responses that drive systemic immune senescence and secondary inflammatory signaling.
DNA Repair Dynamics
PARP · BRCA · Excision Repair
High DNA damage loads exhaust cellular NAD+ pools and provoke danger-sensing pathways when genomic repair mechanisms are overwhelmed.
Metabolic Signaling
AMPK · FOXO · IGF-1
Nutrient-sensing cascades govern the balance between growth signaling and cellular maintenance, interfacing directly with leukocyte resolution programs.
Diagnostic Boundary: The Inflammation Compass™ is a whole-blood RNA sequencing test performed by Biomeme Labs. It evaluates systemic inflammatory and resolution programs across the 3 Health Domains. It does not run direct biopsy assays, isolated tissue enzyme measurements, or standalone telomerase assays.
Explore by
Intervention
More longevity interventions coming soon — including rapamycin, metformin, and senolytic monitoring.
Aging Clocks vs.
Pathway Intelligence
Epigenetic Age Tests
Give you a single number — your biological age. Useful as a snapshot, but can't tell you which pathways to target or whether your interventions are working on those specific pathways.
- • Single summary number
- • No pathway-level detail
- • Can't attribute changes to specific interventions
Inflammation Compass™
Gives you domain-level resolution across the 3 Health Domains (Activation, Antiviral Response, Resolution) plus cellular deconvolution. See whether systemic inflammaging is calming and whether active resolution machinery is engaged. Not an arbitrary single score — dynamic molecular intelligence.
- ✓ 3 Health Domains + Cellular Deconvolution
- ✓ Dynamic leukocyte RNA expression
- ✓ Longitudinal intervention monitoring
Aging clocks and transcriptomic monitoring are complementary. One gives you a static estimate — the other reveals active cellular defense and resolution capacity.
Your Longevity
Data Awaits
The Inflammation Compass™ is available now to establish your baseline and track real-time systemic inflammatory calming and resolution capacity across your longevity protocols.