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What GLP-1 medications do, and where they fall short.

Plain guides to Ozempic, Wegovy, Mounjaro and Zepbound: the benefits and trade-offs seen in trials, why weight loss levels off, and questions to take to your prescriber. Every figure links to its source.

The medication facts first,
with the source beside each one.

These guides describe what large trials found about GLP-1 medications, on both sides of the ledger, and link each figure to the study it came from. They are written to help you prepare for conversations with your prescriber. Decisions about starting, adjusting or stopping a medication stay with you and your prescriber.

The guides

  • Benefits and trade-offs of GLP-1 medications

    What the trials found on weight, blood sugar, heart outcomes and inflammation, and the side effects, costs and open questions that come with them.

  • When weight loss slows or stalls

    Why weight loss levels off within the first year, how often trial participants lost less than 5% of body weight, the factors researchers have looked at, and questions to take to your prescriber.

Alongside your therapy,
see what changes in your inflammation.

The Inflammation Compass is a blood test that reads which genes your immune cells are using. It shows which parts of your inflammation system are active today, how that compares with people measured the same way, and, from your second sample, which of your six readings moved and by how much. It adds to the labs your prescriber orders and doesn’t replace them, and it doesn’t show whether a medication is working.

  • GLP-1 and inflammation

    What the trials show about GLP-1 medicines and inflammation, and what the Inflammation Compass shows across your samples.

  • What the test measures

    Six readings across Activation and Resolution, from 38 pathways, plus your immune cell mix.

  • When to give a sample

    A suggested cadence: a baseline, then samples around dose changes, maintenance or a taper. You choose how often.

  • Lean mass on GLP-1 therapy

    What trials found about lean mass loss, and how body-composition scans such as DXA measure it.

  • The science, with sources

    The research on GLP-1 therapy and inflammation, and how whole-blood RNA sequencing becomes six readings.

Bring your prescriber a detailed read of your inflammation response.

Every result is explained: what was measured, how it was calculated and who you're compared with.